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Complex regional pain syndrome (CRPS)| Primary Research (KOL’s Insight) | Market Intelligence | Epidemiology & Market Forecast-2030

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Complex regional pain syndrome (CRPS) is a chronic pain condition characterized by spontaneous and evoked regional pain, usually starting in a distal extremity, which is disproportionate in magnitude or duration to the typical pain course after similar tissue trauma. Current treatment for CRPS requires a multidisciplinary approach involving patient education, physical and occupational therapy, psychiatry and pain medicine specialists, along with pharmacological and surgical interventions. Unfortunately, the current available treatment options are generally considered to be ineffective and one-dimensional, as they only treat part of the disease. Emerging therapies like Soticlestat (Takeda / Ovid Therapeutics and Lanicemine (AstraZeneca / Biohaven Pharmaceuticals) is expected to generate more market share than other emerging therapies and have the potential to overcome the treatment barrier.

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Description

Complex regional pain syndrome (CRPS; formerly known as RSD or reflex sympathetic dystrophy) is defined as a debilitating chronic pain condition characterized by severe pain along with sensory, autonomic, motor and trophic impairment often involving hyperalgesia and allodynia of the extremities.

Originally classified by the International Association for the Study of Pain (IASP) in 1994 and formally updated to accept the Budapest Criteria of 2003 due to the increased statistical measures and currently considered the most accepted diagnostic approach, the classification of CRPS brings about two different etiologies with differing presentations: a) CRPS type I (previously Reflex Sympathetic Dystrophy) develops after trauma or injury and does not involve a specific peripheral nerve and b) CRPS type II (previously Causalgia) develops after peripheral nerve injury. CRPS is more common in women but can occur in anyone at any age, peaking around the age of 40. It is rare in the elderly, who have less inflammation after injury, and in young children who heal so quickly and completely.

Complex regional pain syndrome – Prevalence (Epidemiology)

The diagnosis of CRPS is mainly based on clinical features, internationally recognized diagnostic and research criteria, the Budapest criteria, which were previously developed by a group of experts to improve the recognition of this syndrome. Despite the availability of the Budapest diagnostic criteria, the CRPS diagnosis process is frustrating and tedious for both healthcare professionals and patients. In multiple scenarios, diagnoses took months to years due to the frequent occurrence of misdiagnoses. There is limited awareness among healthcare professionals of a specific diagnostic algorithm or tool to confirm the condition and hence there is a great unmet need for advancement of diagnostic criteria and diagnosis.
“The total prevalent cases in the G7 countries are anticipated to rise from 253,603 in 2017 to XXX by 2030 at a CAGR of XX% for the study period (2017–2030).The United States was estimated to have the highest prevalence of Complex regional pain syndrome (CRPS) cases in 2017.”Complex regional pain syndrome CRPS I CRPS II Epidem

Complex region pain Syndrome – Current Market Size & Forecast Trends

Unfortunately, the current treatment options available are generally considered ineffective and unidimensional, which are treating only a part of the disease. At present, physical therapy and pharmacological interventions consisting of non-steroidal anti-inflammatory drugs (NSAID), corticosteroids have been used as first-line treatment for pain and inflammation associated with CRPS in both adults and pediatric patients. However, as patients proceed to second-line and third-line treatment, various side-effects such as weight gain, sleep disturbances, gastrointestinal problems, become a major treatment concern. Last-line of treatments consists of opioids which is rarely used in case of CRPS and surgical approaches such as spinal cord stimulators and ketamine, but they involve high-cost and huge treatment risks.

“There is only one effective treatment approved for complex regional pain syndrome in Italy with access to EU neighboring countries and also used off label in the United States. According to the experts, Neridronate is the right path towards an actual cure. If caught on time, in 80% of cases, CRPS actually disappears and none of the patients notices a return of the symptoms after the treatment. Ninety-seven percent of patients showed much improvement after Neridronate infusions.”

Complex regional pain syndrome - Treatment paradigmThe Complex regional pain syndrome (CRPS) therapeutic market is expected to increase at a significant rate during the figure time frame, 2021 to 2030. In 2021, the market is developing at a consistent rate and the is relied upon to ascend over the projected horizon with the rise in adoption strategies by key market players. The therapy market is expected to experience high growth throughout our study period, increasing from  2017 to 2030 from USD XXX million to USD 0.95 billion, representing  compound annual growth (CAGR) of XX%. Primary drivers of this growth will be the launch of the new drugs i.e., Neridronate/Nerixia (Abiogen Pharma/Grünenthal), Soticlestat (Takeda/Ovid Therapeutics), Lanicemine (AstraZeneca/Biohaven Pharmaceuticals) and Low dose naltrexone (Soin Therapeutics).

Complex regional pain syndrome - Market Forecast 2030

Report Highlights

  • Complex regional pain syndrome (CRPS)– Current Market Trends
  • Complex regional pain syndrome (CRPS)– Current & Forecasted Cases across the G7 Countries
  • Complex regional pain syndrome (CRPS)– Market Opportunities and Sales Potential for Agents
  • Complex regional pain syndrome (CRPS)– Patient-based Market Forecast to 2030
  • Complex regional pain syndrome (CRPS)– Untapped Business Opportunities
  • Complex regional pain syndrome (CRPS)– Product Positioning Vis-a-vis Competitors’ Products
  • Complex regional pain syndrome (CRPS)– KOLs Insight

Additional information

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Table of Contents

      • Executive Summary
        • Key Findings
      • Complex regional pain syndrome (CRPS) Disease Background
        • Complex regional pain syndrome (CRPS) Definition
        • Symptoms & Causes
        • Classifications
        • Stages
        • Pathophysiology
        • Diagnosis & Diagnostic Criteria
        • Differential Diagnosis
      • Epidemiology and Patient Populations
        • Key Findings
        • Methods and data Sources
          • Country Specific Prevalent Population with Complex regional pain syndrome (CRPS) (US, Germany, France, Italy, Spain, UK, and Japan)
          • Country Type-Specific Cases with Complex regional pain syndrome (CRPS) (CRPS-I & CRPS-II)
          • Country Specific Diagnosed and Treatable Cases of Complex regional pain syndrome (CRPS)
        • Key Sources for Complex regional pain syndrome (CRPS) Epidemiology and Model Parameters
          • United States
            • United States Prevalent Population with Complex regional pain syndrome (CRPS)
            • United States Type-specific cases with Complex regional pain syndrome (CRPS) (CRPS-I & CRPS-II)
            • United States Diagnosed and Treatable Cases of Complex regional pain syndrome (CRPS)
          • Germany
            • Germany Prevalent Population with Complex regional pain syndrome (CRPS)
            • Germany Type-specific cases with Complex regional pain syndrome (CRPS) (CRPS-I & CRPS-II)
            • Germany Diagnosed and Treatable Cases of Complex regional pain syndrome (CRPS)
          • France
            • France Prevalent Population with Complex regional pain syndrome (CRPS)
            • France Type-specific cases with Complex regional pain syndrome (CRPS) (CRPS-I & CRPS-II)
            • France Diagnosed and Treatable Cases of Complex regional pain syndrome (CRPS)
          • Italy
            • Italy Prevalent Population with Complex regional pain syndrome (CRPS)
            • Italy Type-specific cases with Complex regional pain syndrome (CRPS) (CRPS-I & CRPS-II)
            • Italy Diagnosed and Treatable Cases of Complex regional pain syndrome (CRPS)
          • Spain
            • Spain Prevalent Population with Complex regional pain syndrome (CRPS)
            • Spain Type-specific cases with Complex regional pain syndrome (CRPS) (CRPS-I & CRPS-II)
            • Spain Diagnosed and Treatable Cases of Complex regional pain syndrome (CRPS)
          • United Kingdom
            • United Kingdom Prevalent Population with Complex regional pain syndrome (CRPS)
            • United Kingdom Type-specific cases with Complex regional pain syndrome (CRPS) (CRPS-I & CRPS-II)
            • United Kingdom Diagnosed and Treatable Cases of Complex regional pain syndrome (CRPS)
          • Japan
            • Japan Prevalent Population with Complex regional pain syndrome (CRPS)
            • Japan Type-specific cases with Complex regional pain syndrome (CRPS) (CRPS-I & CRPS-II)
            • Japan Diagnosed and Treatable Cases of Complex regional pain syndrome (CRPS)
      • Current Therapies and Medical Practice
        • Treatments & Medical Practices
        • Pharmacological Approach
        • UK Pharmacological Guidelines
        • Non-Pharmacological Approach
        • Surgical Approach
        • Treatment Paradigm
      • Marketed Drug
        • Neridronate (Abiogen Pharma/Grünenthal) (Marketed in Italy)
              • Product Profile
              • Clinical Development
              • Sales & Market Opportunity by 2030
      • Unmet Needs
      • Emerging Therapies
        • Pipeline Overview
        • Therapeutic Developments Pipeline for Complex regional pain syndrome (CRPS)
          • Product Analysis
            • Soticlestat (Takeda/Ovid Therapeutics)
              • Product Profile
              • Clinical Development
              • Sales & Market Opportunity by 2030
            • Lanicemine (AstraZeneca/Biohaven Pharmaceutical)
              • Product Profile
              • Clinical Development
              • Sales & Market Opportunity by 2030
            • Ketamine (iX Biopharma)
              • Product Profile
              • Clinical Development
              • Sales & Market Opportunity by 2030
            • PPP-001 (Tetra Bio-Pharma)
              • Product Profile
              • Clinical Development
              • Sales & Market Opportunity by 2030
            • Low dose naltrexone (Soin Therapeutics)
              • Product Profile
            • Ketamine (Bexson Biomedical)
              • Product Profile
      • Complex regional pain syndrome (CRPS)- Pricing & Reimbursement
      • Future Treatment Paradigm
        • Complex regional pain syndrome (CRPS) Competitor Landscape and Approvals Anticipated
        • Future Treatment Algorithms and Competitor Positioning
        • Key Data Summary for Emerging Treatment
      • Annual Cost of Current & Emerging Therapies
      • Market Outlook
        • Key Findings
        • Country Specific Market Forecast to 2030
          • Sales of Drugs to Treat Complex regional pain syndrome (CRPS) in the Major Pharmaceutical Markets, 2017-2030
          • Patient Share of Complex regional pain syndrome (CRPS) Therapies and by Drug
      • Market Forecast by Country
        • United States
          • United States Market for Complex regional pain syndrome (CRPS) 2020-2030 (USD Million)
          • United States Market for Complex regional pain syndrome (CRPS) by Therapies 2020-2030 (USD Million)
        • Germany
          • Germany Market for Complex regional pain syndrome (CRPS) 2020-2030 (USD Million)
          • Germany Market for Complex regional pain syndrome (CRPS) by Therapies 2020-2030 (USD Million)
        • France
          • France Market for Complex regional pain syndrome (CRPS) 2020-2030 (USD Million)
          • France Market for Complex regional pain syndrome (CRPS) by Therapies 2020-2030 (USD Million)
        • Italy
          • Italy Market for Complex regional pain syndrome (CRPS) 2020-2030 (USD Million)
          • Italy Market for Complex regional pain syndrome (CRPS) by Therapies 2020-2030 (USD Million)
        • Spain
          • Spain Market for Complex regional pain syndrome (CRPS) 2020-2030 (USD Million)
          • Spain Market for Complex regional pain syndrome (CRPS) by Therapies 2020-2030 (USD Million)
        • United Kingdom
          • United Kingdom Market for Complex regional pain syndrome (CRPS) 2020-2030 (USD Million)
          • United Kingdom Market for Complex regional pain syndrome (CRPS) by Therapies 2020-2030 (USD Million)
        • Japan
          • Japan Market for Complex regional pain syndrome (CRPS) 2020-2030 (USD Million)
          • Japan Market for Complex regional pain syndrome (CRPS) by Therapies 2020-2030 (USD Million)
      • Market Drivers and Constraints
        • What Factors Are Driving the Market for Complex regional pain syndrome (CRPS)?
        • What Factors Are Constraining the Market for Complex regional pain syndrome (CRPS)?
      • Appendix
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